FACULTY PROFILE
PALAKSHA K. JAVAREGOWDA
Professor and Principal
PhD: Gyeongsang National University, South Korea
POST-DOC: Inje University & Seoul National University, South Korea and NCCHD, Japan.
Tel: +91 99015 48660 (Mobile)
Background
He obtained his graduation in Fisheries Science and Ph.D. in Veterinary Medicine majoring in Immunology. During his post-graduation, he worked on the development of rapid diagnostic kits and vaccines for aquatic animal pathogens in India and South Korea. In his post-doc, he worked on the effect of tryptophan metabolites on collagen-induced arthritis using mouse model; generation and use of iPSCs (bovine, porcine, mouse, and human) as donor cells for SCNT (bovine & porcine) and rejuvenating aged oocytes (mouse); and hepatic differentiation of hiPSC/hESCs to develop cell therapy and drug metabolism models. During the past decade, he is working with eminent scientists and clinicians from South Korea, Japan, and United Kingdom to develop cell/stem cell therapy products to treat orthopedic disorders, liver disease and 3D cell culture systems for drug metabolism and toxicity studies. He has experience of teaching immunology and proteomics courses to post-graduate students. Moreover, he has worked with multiple companies as an assistant manager of R&D and technical advisor for designing and construction of research laboratories and clean rooms in India and abroad.
Areas of Research:
Generation of human iPSCs (normal and Patient/disease-specific) and their utilization in the systematic understanding of disease mechanisms and regenerative medicine.
Development of hiPSCs derived hepatocytes like cells/hepatocytes spheroids and organoids culture (3D models) for disease, drug metabolism, and toxicity studies.
Development and validation of cell and cell-derived products for the regeneration of damaged cartilage, bone, and skin.
Selected publications
- Huh SW, Shetty AA, Kim JM, Cho ML, Kim SA, Yang SY, Kim YJ, Palaksha KJ, Choi NY, Kang J, Kim SJ. (2016). Autologous bone marrow mesenchymal cell induced chondrogenesis for the treatment of osteoarthritis of the knee. Tissue Engineering and Regenerative Medicine. 13 (2); 200-209.
- Veena Shetty A, Geethashri A, Palaksha KJ, Sridhar KR, Sanjeev G. (2014). Antimicrobial activity and stability of electron beam irradiated dental irrigants. Journal of Clinical & Diagnostic Research. 8 (11): DC21-24.
- Kim SJ, Ok Jae Koo OJ, Park HJ, Moon JH, da Torre BR, Palaksha KJ, Kang JT, Park SJ, Saadeldin IM, Choi JY, Lee BC, Jang G. (2014). Oct4 overexpression facilitates the proliferation of porcine fibroblasts and the development of cloned embryos. Zygote. 2: 1-8.
- Palaksha KJ, Shin GW, Kim YR, Jung TS (2008). Evaluation of non-specific immune components from the skin mucus of olive flounder (Paralichthys olivaceus). Fish and Shellfish Immunology. 24 (4): 479-488.
- Shin GW, Palaksha KJ, Kim YR, Nho SW, Heo GJ, Park SC, Jung TS. (2007). Application of immunoproteomics in developing S. iniae vaccine for olive flounder (Paralichthys olivaceus). Journal of Chromatography B: Biomedical Sciences and Applications. 849 (1-2): 315-322.
RENUKARADHYA K. MATH, Associate Professor
Ph.D.: Gyeongsang National University, South Korea
POST-DOC: Chung-Ang University, South Korea
Research Fellowship: Young Investigator Research Fellowship, Chung-Ang University, South Korea
E-mail: aradhya@sdmuniversity.edu.inTe1:+917019982929 (Mobile)
Academic & industrial career: He obtained a Bachelor's degree from Karnataka University, Dharwad, discipline in Chemistry, Botany, Zoology (CBZ) in the year 2002. Then, a Master’s degree in Biotechnology from Bangalore University in the year 2004. He received his Doctoral degree in the year 2010 under the guidance of Professor Han Dae Yun from Gyeongsang National University, South Korea. During his Ph.D., he worked on several topics like the construction of 16S rDNA library of the rumen, oyster dumps, and soil samples, a metagenomic study of fermented food samples, vector construction for mushroom transformation, endophytic bacteria and understanding protein-clay mineral binding mechanism using microscopic techniques like confocal, fluorescence, AFM, and FTIR, etc. During his Post-Doc at Chung-Ang University under the guidance of Professor Che Ok Jeon, he worked on a comparative genomics study of a bacterium and carried out several bacterial taxonomic studies. In the year 2013, he joined Garden City College as an Assistant Professor in the Department of Biotechnology, Bengaluru. After working for two and a half year he later joined a start-up company (2016) in Bengaluru, where they developed a bio-membrane to purify the air. Throughout his research career, he has interacted with several national & international scientists and presented conference papers. He has 27 international peer-reviewed publications to his credit.
Area of Research:
- Gut-microbiome & Human health i) Gut microbial ecology & taxonomy ii) Multi-Omics approach to understanding the human gut microbiome, health and disease iii) Understanding gut-liver, gut-pancreas and gut-brain axis as a long term goal.
- Nano-Biotechnology
Selected Publications:
- Renukaradhya K. Math, Srinivasa Reddy, Han DY, Devaiah K, Ghebreiyessus Y. (2019). Modeling the clay minerals-enzyme binding by fusion fluorescent proteins and under the atomic force microscope. Microscopic Research and Technologies.
- Renukaradhya K. Math, Devaiah K, Han DY, and Ghebreiyessus Y. (2020). Binding of cloned Cel enzymes on clay minerals related to the pI of the enzymes and database survey of cellulases of soil bacteria for pI, Bioscience, Biotechnology, and Biochemistry, 84:2, 238-246.
- Renukaradhya K. Math, Hyun MJ, Jeong SH and Jeon CO (2013). Defluviimonas aestuarii sp. nov., a marine bacterium isolated from a tidal flat of South Sea in Korea. International Journal of Systematic and Evolutionary Microbiology. 63, 2895-2900.
- Renukaradhya K. Math, Hyun MJ, Kim JM, Lee KS, Hahn YS, Park WJ, Madsen EL, Jeon CO. Comparative genomics reveals adaptation by Alteromonas sp. SN2 to marine tidal-flat condition: cold tolerance and aromatic hydrocarbon metabolism. PLoS ONE. 2012;7(4): e35784.
AJAY KUMAR OLI
Additional Associate Professor
Ph.D. (Biotechnology): Gulbarga University
E-mail: ajaykumar@sdmuniversity.edu.in
Background:
He acquired M. Sc. in Biotechnology and later worked as Research Trainer under DBT BCIL at Symbiosis Pvt. Ltd Bangalore. In his Ph.D. program, he worked on bacteriophage therapy against multidrug Gram-Positive bacteria in Animal Model. Further, he went on to work as Assistant Professor at VGS College, Solapur University, Solapur where he was actively involved in academics and research and had been a member of BOE, BOS Member for SUS-PET and syllabus setter for M. Sc. CBCS Pattern Solapur University, Solapur during. He has also been an external examiner for other universities during this tenure.
Areas of Research:
Autoimmune and Inflammatory diseases:
Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation, the etiology of which is still unclear. Dietary habits and lifestyles have been implicated as environmental factors influencing and increasing the incidence of IBD. Thus, the present study is looking for IBD associated risk factors among the patients visiting SDM Hospital, Dharwad. However, further systematic study will be helpful in identifying associated risk factors and developing regional or community-based health management strategies for IBD.
Selected Five Best Publications:
- Raju S, Ajay Kumar O, Patil SA, Chandrakanth KR. (2010). Prevalence of multidrug-resistant Staphylococcus aureus in diabetics clinical samples. World Journal of Microbiology and Biotechnology. 26 (1): 171-176.
- Ajay Kumar O, Raju S, Rajeshwari NS, Chandrakanth KR. (2012). Biofilm formation by Multidrug-resistant Enterococcus faecalis (MDEF) originated from clinical samples. Journal of Microbiology and Biotechnology Research. 2(2): 284-288.
- Ajay Kumar O, Raju S, Nagaveni S, Rajeshwari H, Chandrakanth KR. (2012). A Study of Scanning electron microscope of vancomycin-resistant Enterococcus faecalis from clinical isolates. Advances in Microbiology. 2 (2): 93-97.
- Nagaveni S, Rajeshwari H, Ahmed L, Ajay Kumar O, Syed S, Sharanbassappa S, Shripad AP, Chandrakanth KR. (2014). Experimental protection of diabetic mice against lethal P. aeruginosa infection by bacteriophage. Biomedical Research International Journal. 1-11.
- Prabhurajeshwar, Ajay Kumar O, Ashajyothi C, Chandrakanth KR. (2015). Prevalence and antibiotic susceptibility pattern of fluoroquinolone-resistant Shigella species isolated from infants stool in Gulbarga district, Karnataka, India. Asian Pacific Journal of Tropical Disease. 5(1): S116-S120.
RENUKA PANCHAGAVI (B.E, M.Tech, M.S., Ph.D.), Assistant Professor
Ph.D.: Computational Science and Engineering.
POST-DOC: Biomedical Informatics and Computational Biology,
Research Fellowship: BEACON NSF Research Traineeship.
E-mail: renuka.panchagavi@sdmuniversity.edu.in Mobile: +91-8105583535Academics & Experience:
She received her Ph.D. in Computational Science and Engineering from North Carolina Agricultural & Technical State University, USA, and M.S in Computer Science Engineering from Ohio State University, USA. During her PhD, she participated as a High-Throughput Researcher in the NSF RCN HITS program. She worked as a Graduate Trainee for the IBIEM (Integrative Bioinformatics for Investigating and Engineering Microbiomes) program at Duke University, USA. where she gained substantial experience in metagenomic analysis (16S, 18S and ITS) using bioinformatics tools - QIIME, Mothur, DADA2 and Deblur. Her doctoral research work involves studying gut microbiome dynamics in human and livestock and Cost-Effectiveness Modeling of Host-Microbiome Investigations using statistical modeling/simulation for analyzing how scientific outcomes relate to economic factors and objectives for investigations of gut microbiome dynamics.
Her work as Postdoctoral Fellow in Bhasin Laboratory, Department of Pediatrics, Emory School of Medicine involves performing single cell analysis of pediatric tumors for determining the role of tumor and microenvironment cells in therapeutic response. Her work as Research Associate in Biomedical Informatics at the Ohio State University involves developing a Predictive Model of Pressure Ulcers in Critical Care Patients using Electronic Health Records Data. She has worked on various NIH and NSF Research Projects. Her research interests are – Biomedical Informatics, Host-Microbiome Dynamics, Cancer therapeutics, Computational Genomics, Machine Learning, and Statistical Modeling.
Areas of Research:
Focus of research would be to deepen our understanding of the human gut microbial dynamics and its impact on human health and diseases.
- Multi-omics analysis, Modeling and Simulation of gut microbial populations with respect to species interaction network, correlation network, and intrinsic growth rates to understand gut microbiome dynamics in humans with a long-term goal of understanding gut-liver, gut-pancreas, and gut-brain axis.
- Explore Cellular Diversity and Transcriptional Variation in the Human Gut through studying Single-cell RNA sequencing (scRNA-seq) techniques with the goal of developing therapeutics for a variety of intestinal diseases.
- Develop a Predictive Model for modeling Risks of Antibiotics resistance using Electronic Health Records Data by applying machine learning techniques to improve prescription.
Selected publications:
- Carley, L. N., Panchagavi, R., Song, X., Davenport, S., Bergemann, C. M., McCumber, A. W., ... & Simonin, M. (2020). Long-Term Effects of Copper Nanopesticides on Soil and Sediment Community Diversity in Two Outdoor Mesocosm Experiments. Environmental Science & Technology, 54(14), 8878-8889.
- Joseph, G., Zhang, B., Harrison, S. H., Graves Jr, J. L., Thomas, M. D., Panchagavi, R., ... & Wang, L. (2020). Microbial community dynamics during anaerobic co-digestion of corn stover and swine manure at different solid content, carbon to nitrogen ratio and effluent volumetric percentages. Journal of Environmental Science and Health, Part A, 55(9), 1111-1124.
- Panchagavi, R., Harrison, S. H. (2019b). “Cost Variables in Host-Microbiome Investigations”. CAMARADES Preclinical Systematic Review & Meta-analysis Facility (SyRF). October 23, 2019. http://syrf.org.uk/protocols/
- Panchagavi, R. (2012). Survey of Electronic Health Records Data for Developing a Predictive Model of Pressure Ulcers in Critical Care Patients (Master’s Thesis; Ohio State University, Columbus, OH;). Retrieved from https://etd.ohiolink.edu/.
AJAY S. K., Assistant Professor
Ph.D. (Biochemistry): NITTE Deemed to be University
E-mail: ajaysk@sdmuniversity.edu.in
Te1:+91 9036883271
Background:
He acquired M. Sc. in Biochemistry from PG Davanagere, Kuvempu University and after working as a lecturer in Biochemistry at St. Aloysius College, Mangalore. In his Ph.D. program, he worked on isolation and characterization of trypsin enzyme from fish and its bactericidal effect. Worked as JRF and SRF in the MoES project and awarded a Ph.D. from NITTE deemed to be University. Further, he went on to work as Assistant Professor of Biochemistry, College Fisheries, Mangalore, he was actively involved in academics and research. He has also been an external examiner and BOS and BOE member for other universities and colleges during this tenure.
Areas of Research:
- The Intricate relationship between Gut microbiota and Pancreatic health & diseases—experimental and clinical approaches to untie the interaction between pancreas & gut microbiota.
- Development of patient tissue-derived primary cell cultures and cell-based assay for drug screening and toxicological studies.
- In-vitro evaluation of pharmacological properties of natural products—Ayurveda and Marine.
Selected Five Best Publications:
- Ajay SK, Sarojini BK, Suchetha Kumari N, Joshi SDS and Krishnaprasad N. (2015). Isolation, Purification and Biochemical Characterization of Trypsin from Indian Mackerel (Rastralliger Kanagurta). Journal of Aquatic Food Product and Technology. 24(4), 354-367
- Nivya MT, Rajashekhar K Patil, Gopal M. Advi Rao, Ajay SK, Somashekrappa HM, Ananda D, Manjunath HM, and Joshi CG. (2019). Cytotoxicity Based Screening for Radio Protective Properties of Methanolic Extracts of Tragia involucrata L. on Cultured Human Peripheral Lymphocytes Exposed to Gamma Radiation. Indian Journal of Experimental Biology. 57, 469-477.
- Nivya MT, Joshi CH, Rajashekhar K. Patil, Ajay SK, Somashekarappa HM, Ananda D, and Manjunath HM. (2019). Mitigation of Radiation-Induced Oxidative Stress by Methanolic Extract of Tragia involucrata in Swiss Albino Mice. Pharmacognosy Research. 11(3). 236-243.
- Girish SK, Puneeth TG, Nithin MS, Naveenkumar BT, Ajay SK, Vinay TN, Suresh T, Venugopal MN and Ramesh KS (2019). Red sea bream iridovirus disease (RSIVD) outbreak in Asian seabass (Lates calcarifer) cultured in open estuarine cages along the west coast of India: First, report. Aquaculture.520, 1-5
- Goveas JJ, Ajay SK, Shetty S, Gonsalves RA. (2019) Photocatalytic, anti-microbial, antioxidant and cytotoxic activity of electrochemically synthesized ZnO-TiO2 nanostructures. Research Journal of Chemical Sciences. Accepted and in press
PRABHANJAN P. GAI
(B.E, M.Tech, Ph.D.)
Assistant Professor
Ph.D.: Freie Universität Berlin, in co-operation with Charité – Universitätsmedizin Berlin, Germany
E-mail: prabhanjan.gai@sdmuniversity.edu.in
Tel: +91 (0) 836 2477336
Background:
Dr. Prabhanjan Gai obtained his Bachelor of Engineering in Biotechnology from B. V. Bhoomaraddi College of Engineering & Technology, Hubli, and Master of Technology in Biotechnology with highest honors (Gold Medal) from Sri Jayachamarajendra College of Engineering, Mysore, Karnataka, India. He completed his M. Tech project at the Institute for Tropical Medicine, University of Tuebingen, Germany. Dr. Gai then got selected in an international Ph.D. program (funded by the German Research Foundation) at the Freie Universität Berlin, Germany, in co-operation with Charité – Universitätsmedizin Berlin, Germany. He was working in the malaria and infectious disease epidemiology lab at the Institute of Tropical Medicine and International Health (ITMIH), Berlin, Germany. He defended the Ph.D. thesis in Biomedical Sciences with great honors (German grade: Magna Cum Laude).
His work focused on investigating the host and parasite genetic factors influencing the risk and manifestation of malaria in India and Africa. Primarily he was interested in the functional human genetic polymorphisms, their role in the pathophysiology of Plasmodium vivax and Plasmodium falciparum infection. Secondarily, to identify the molecular markers in Plasmodium parasites leading to anti-malarial drug resistance. In addition to malaria, during his tenure as a Research Associate in the ITMIH, his work also aimed at identifying and assessing the host genetic determinants of dengue in Sri Lanka. Furthermore, he has experience in the development and evaluation of RT-PCR-based kits for the diagnosis of various diseases. He is experienced in grass-root organization, set up, and management of scientific projects. Dr. Gai has been actively involved in several international collaborative projects in Germany, Sri Lanka, and Rwanda.
Areas of Research:
The focus would be on evaluating the role of human genetic polymorphisms and their gene products influencing the immune response to and the manifestation of infectious diseases (e.g. Malaria, Dengue ,etc.) as well as to identify molecular markers of drug resistance. Further interests are to understand the correlation between a three-way axis of host- pathogen-microbiota.
Selected Five Best Publications
- Gai PP, van Loon W, Siegert K, Wedam J, Kulkarni SS, Rasalkar R, et al. Duffy antigen receptor for chemokines gene polymorphisms and malaria in Mangaluru, India. Malar J. 2019;18:328.
- Gai PP, Mockenhaupt FP, Siegert K, Wedam J, Boloor A, Kulkarni SS, Rasalkar R, Kumar A, Jain A, Mahabala C, Gai P, Baliga S, Devi R, Shenoy D. Manifestation of malaria in Mangaluru, southern India. Malar J. 2018;17:313.
- Bedu-Addo G, Gai PP, Meese S, Eggelte TA, Thangaraj K, Mockenhaupt FP. Reduced prevalence of placental malaria in primiparae with blood group O. Malar J. 2014;13: p.289
- Tacoli C, Gai PP, Siegert K, Wedam J, Kulkarni SS, Rasalkar R, Boloor A, Jain A, Mahabala C, Baliga S, Shenoy D, Gai P, Devi R, Mockenhaupt FP. Characterization of Plasmodium vivax pvmdr1 polymorphisms in isolates from Mangaluru, India. Am J Trop Med Hyg. 2016 Nov 2;95(5):1090-1093.
- Tacoli C, Gai PP, Bayingana C, Sifft K, Geus D, Ndoli J, Sendegeya A, Gahutu JB, Mockenhaupt FP. Artemisinin resistance-associated K13 polymorphisms of Plasmodium falciparum in Southern Rwanda, 2010-2015. Am J Trop Med Hyg. 2016;95:1090-1093.
MALLIKARJUN GONI, Research Associate
M. Sc., PGDIPR, (Ph.D. at VTU, Belgaum)
E-mail: mallikarjung@sdmuniversity.edu.in
Background
Accomplished postgraduate degree in Biotechnology from Gulbarga University, Gulbarga. He has four years of industry experience in Regenerative Medicine where he was actively involved in cell therapy, stem cell processing, banking, and cryostorage. To add to his experience, he is also trained in quality assurance of cell and cell-based products, documentation with respect to compliance with FDA, BSI (ISO13485), GMP, GLP, and GDP. At present, he is perusing his Ph.D. in Biotechnology specializing in Cancer Glycobiology.
Areas of Research:
Cancer Glycobiology:
- Understanding of glycobiology of cancer progression, metastasis, and resistance to therapy.
- Studying the role of aberrant glycosylation process involved in inflammatory disorders in order to develop immunotherapies to treat cancer and other inflammatory disorders.
APOORVA JAIN, Research Assistant
M.Sc. Biotechnology
Background
Ms. Apoorva Jain obtained her Bachelor's degree from Karnataka University, Dharwad, majoring in Chemistry, Zoology, and Biotechnology in the year 2016. Then, a Master’s degree in Biotechnology from Mysore University in the year 2018. Has done an Internship for one month in Bhat Bio-tech India Pvt. Ltd. there she had hands-on experience in overexpression and the uses of Recombinant proteins for diagnostics. Later worked as a Research Assistant in the Biogenics-Research center. Hubballi. for one year. Where she had experience in Antimicrobial analysis, Gel Electrophoresis, Chromatography, and PCR.
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